In a 2008 French study published in Alimentary Pharmacology & Therapeutics, researchers identified NSAID use as a potential risk factor for developing GERD. 6,823 questionnaires were assessed by the research team, which revealed that 2,262 adults had used NSAIDs within the last three months. Prevalence rates for acid regurgitation and heartburn symptoms during the three-month period stood at 21%, with older adults being most affected. The average lifetime prevalence rate for GERD was found to be 37%.

Experts at PharmEasy explain that the relationship between ibuprofen and GERD symptoms can be explained by the fact that the medication boosts stomach acid production. Ibuprofen can also cause damage to the lining of the stomach, which may lead to inflammation. It also hinders the production of prostaglandins, which act similarly to hormones and play a role in pain, inflammation, and uterine contractions during one’s period (via Cleveland Clinic). Prostaglandins also protect the digestive tract, otherwise leaving you vulnerable to gastrointestinal symptoms.