While health conditions such as hypothyroidism and Cushing’s syndrome — a condition characterized by an overproduction of cortisol in the body — can prompt cases of moon face, fans were primarily speculating as to whether Schumer’s appearance may potentially be related to prednisone use. As a result, Google searches for “Prednisone Face Swelling” have been up by 300% since yesterday.

Prednisone, a prescription corticosteroid medication, can be used to treat a variety of inflammatory conditions, including allergies, arthritis, skin conditions, psoriasis, and more (via Drugs.com). A number of side effects have been noted in association with the drug, such as insomnia, mood changes, stomach pain, headache, bloating, and acne. Prednisone has also been shown to potentially increase one’s appetite, prompt gradual weight gain, or induce changes in the shape or distribution of body fat. Areas that may be affected include both the face and neck, among other regions.

If the occurrence of moon face is related to a specific health condition, treating the underlying condition can help reduce facial swelling. For cases of moon face related to steroid use, talking to one’s doctor about using an alternate steroid medication or adjusting the dosage may prove helpful.